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Management of Long-term pain continues to depict a region of terrific unmet biomedical require. While opioid analgesics are generally embraced given that the mainstay of pharmaceutical interventions in this space, they are afflicted with substantial liabilities that include dependancy and tolerance, together with despair of breathing, nausea and Pe

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2005). These benefits were not astonishing if we take into consideration that PEA is often a badly h2o‐soluble material, which might limit its oral absorption and bioavailability, but they may additionally counsel a brief‐lived action of PEA, in agreement with The truth that this compound is degraded by two different hydrolases, that is, NAAA a

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